Febuxostat

Classification: API

English name: Febuxostat

CAS No.: 144060-53-7

Chinese synonym: 2-[3-cyano-4-isobutoxyphenyl]-4-methylthiazole-5-carboxylic acid; febuxostat/2-[3-cyano-4-isobutoxy Phenyl]-4-methylthiazole-5-carboxylic acid; febuxostat (2-[3-cyano-4-isobutoxyphenyl]-4-methylthiazole-5-carboxylic acid); Febuxostat-mixed crystal; febuxostat-A; febuxostat (this product is not available in the United States); febuxostat; febuxostat

CBNumber: CB4841564

Molecular formula: C16H16N2O3S

Molecular weight: 316.37

Chemical properties: white powder

Uses: Treatment of hyperuricemia (gout)


Product Description

Description

Febuxostat (INN; trade names Adenuric in Europe and New Zealand, Uloric in the US, Goturic in Latin America, Feburic in Japan) is a drug that inhibits xanthine oxidase, thus reducing production of uric acid in the body. It is used in the treatment of chronic gout and hyperuricemia.

Febuxostat was discovered by scientists at the Japanese pharmaceutical company Teijin in 1998. Teijin partnered the drug with TAP Pharmaceuticals in the US and Ipsen in Europe. Ipsen obtained marketing approval for febuxostat from the European Medicines Agency in April 2008, Takeda obtained FDA approval in February 2009, and Teijin obtained approval from the Japanese "Pharmaceuticals and Medical Devices Agency" in 2011.


Basic Info

Chemical Name

2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic acid

Synonyms

2-(3-Cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic Acid;UNII-101V0R1N2E;Febuxostat;Uloric;Adenuric;Febuxostat,This product is unavailable;Tei-6720;TMX 67;

CAS No.

144060-53-7

Molecular Formula

C16H16N2O3S

Molecular Weight

316.37500

PSA

111.45000

LogP

3.72318


Properties

Appearance & Physical State

Crystalline Solid

Density

1.31 g/cm3

Boiling Point

536.6ºC at 760 mmHg

Melting Point

238-239ºC

Flash Point

278.3ºC

Refractive Index

1.605

Vapor Pressure

2.41E-12mmHg at 25°C


Safety Info

HS Code

2934100090



Company Profile

Jinan Xinnuo Pharmaceutical Technology Co., Ltd. is a high-tech enterprise specializing in the production of pharmaceutical intermediates. The company has been engaged in the research, development and production of chemical intermediates for more than 10 years. It integrates research, development, production, import and export trade, strong technical force, advanced testing methods, strong research and development capabilities and superb synthetic technology. It is an incubator of Jinan Pharmaceutical Valley. Committed to gout, nutrition, anti-cancer, anti-depression, anti-age dementia and drug synthesis in the cardiovascular and cerebrovascular fields. The products are mainly exported, and the products are exported to more than 40 countries and regions such as Southeast Asia, South America and Eastern Europe.

The company has a complete quality assurance system and strong scientific research and innovation strength. Every year, new market-oriented and high-tech synthetic drugs are launched. We are willing to provide you with quality products and competitive prices. Efficient service.


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